ScienceDirect
Synthetic And Systems Biotechnology
(ISSN 2405-805X)
Aims & Scope
Synthetic and Systems Biotechnology aims to promote the communication of original research in synthetic and systems biology, with strong emphasis on applications towards biotechnology.
The journal publishes high-quality research; focusing on integrative approaches to enable the understanding and design of biological systems, and research to develop the application of systems and synthetic biology to natural systems. This journal publishes original research articles, review articles, short communications, commentaries, perspectives and research highlights.
The journal covers a wide range of topics, including new technologies, processes, methods, materials, systems, and applications in the field of synthetic and systems biotechnology and biomedicine. Areas of particular interest include, but are by no means limited to:
Production of natural products and other small molecules (e.g., antibiotics and other therapeutics, biofuels, peptides, chemicals, fragrances and flavours)
Engineering of biological pathways and circuits, including computational design and modelling
Synthetic genetic circuits or biosensors for biomedical applications, tissue engineering, and the programming of therapeutic cells
Synthetic biology and nanobiology for biomedical applications
Engineering of optimized general chassis organisms, e.g., by metabolic engineering and genome minimization
Genome construction, editing, and design
Analytical platforms for the debugging of engineered biosystems, including RNA-seq, flow cytometry, and imaging mass spectrometry
Omics including genomics, transcriptomics, proteomics, metabolomics, lipidomics and else
Novel DNA synthesis, assembly and editing methods
Semiconductor synthetic biology: DNA origami, DNA information storage, electronic biomedicine
In vitro, cell-free and artificial systems for biomolecule production and pathway prototyping
Cybergenetics for precision medicine, precision-controlled gene- and cell-based therapies
Viral engineering and synthetic vaccines
Synthetic drug delivery systems
Synthetic immunology, e,g., smart CAR-T, CAR-NK, CAR-M therapies
Mammalian synthetic biology
Enzyme/protein engineering by rational design and directed evolution
Creation of building block, or part, libraries for synthetic biology, including libraries of catalysts, regulators and control elements
Laboratory automation and robotics for synthetic biology and biosystems engineering
Predictive computational and statistical modelling approaches for synthetic biology
Data integration and data management for systems and synthetic biology
Standards and best practices for synthetic biology experimentation and its applications
Economic, regulatory, societal and ethical aspects of advanced industrial applications of synthetic biology